lack of association between ctla-4 a49g polymorphism and vitiligo
نویسندگان
چکیده
background: vitiligo is an acquired skin disorder that selectively destroys melanocytes in epidermis with an unknown etiology. objective: to investigate the exon 1 a49g polymorphism of cytotoxic t lymphocyte antigen-4 (ctla-4) gene in vitiligo patients. methods: the a49g polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) method in 101 patients and 208 normal healthy age/ethnicity matched individuals. results: the frequencies of heterozygote genotypes in patients and controls were found to be 42 (41.6%) of 101 and 85 (40.9%) of 208, respectively. the frequencies of homozygote a and g genotypes were 49 (48.5%) and 10 (9.9%) in 101 patients, whereas, these frequencies in 208 control individuals were 103 (49.5%) and 20 (9.6%), respectively. there was no significant difference between the genotype (p = 0.98) and allele (p = 0.86) frequencies of a49g polymorphism in patients and normal healthy individuals. conclusion: our results indicate that in contrast to several immune mediated disorders, there is no association between ctla-4 a49g gene polymorphism and vitiligo.
منابع مشابه
Lack of Association between ctla-4 A49G Polymorphism and Vitiligo
Background: Vitiligo is an acquired skin disorder that selectively destroys melanocytes in epidermis with an unknown etiology. Objective: To investigate the exon 1 A49G polymorphism of cytotoxic T lymphocyte antigen-4 (ctla-4) gene in vitiligo patients. Methods: The A49G polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method in 101...
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عنوان ژورنال:
iranian journal of immunologyجلد ۲، شماره ۲، صفحات ۹۷-۱۰۲
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